Reduction in mother-to-child transmission of HIV following an integrated couple-community intervention in Mbandaka (DRC)
PDF (French)

Keywords

HIV
PMTCT
community approach
male involvement
viral load
Mbandaka

How to Cite

Reduction in mother-to-child transmission of HIV following an integrated couple-community intervention in Mbandaka (DRC). (2026). REVUE DES SCIENCES DE LA SANTE, 5(1), 152-163. https://doi.org/10.71004/rss.026.v5.i1.63

Abstract

In Central Africa, the effectiveness of programs to prevent mother-to-child transmission (PMTCT) remains limited. This study evaluates the impact of an integrated couple-community approach on the PMTCT care cascade in Mbandaka, Democratic Republic of Congo. A mixed-methods study was conducted. The quasi-experimental quantitative component compared a pre-intervention group (2022–2023, n=450) with a post-intervention group (2024–2025, n=384). The intervention included virological reinforcement, male involvement, community support, and postnatal reminders. The qualitative component explored the perceptions of 30 participants through interviews and focus groups. The intervention significantly improved key indicators. Early initiation of treatment (<20 weeks of gestation) increased from 31.8% to 71.1% (p<0.001), and viral load suppression at delivery increased from 55.1% to 94.0% (RR=5.79). The rate of vertical transmission decreased from 8.4% to 2.6% (p<0.001). Partner involvement in prenatal care increased from 27.8% to 78.9%. Multivariate analysis confirms that early initiation reduces the risk of transmission by 88% (ORa=0.121). Qualitatively, participants reported increased spousal support, reduced stigma, and greater trust in the healthcare system. The integrated couple-community approach drastically reduces vertical HIV transmission. These results argue for decentralizing virological monitoring and institutionalizing male and community involvement in national PMTCT policies.

PDF (French)

References

1. Organisation mondiale de la Santé (OMS). Directives consolidées sur l'utilisation des antirétroviraux pour le traitement et la prévention de l'infection à VIH. Genève: OMS; 2021.

2. Myer L, Dunning L, Lesosky M, Hsiao NY, Phillips TK. Maternal HIV viraemia and vertical transmission: a systematic review and meta-analysis. Lancet HIV. 2023;10(2):e112-21. https://doi.org/10.1016/S2352-3018(22)00301-4

3. UNAIDS. Global HIV & AIDS statistics — Fact sheet. Geneva: UNAIDS; 2024.

4. Mpunga J, Msowoya P, Ng’ambi W. Performance of PMTCT programs in resource-limited settings: A 2024

update. J Global Health. 2024;14:04012. https://doi.org/10.7189/jogh.14.04012

5. Tshilanda M, Kaswa M, Bulabula J. Évaluation de l'Option B+ en Afrique Centrale : Défis de la cascade de soins. Rev Epidemiol Sante Publique. 2023;71(4):101-9.

6. Poundstone KE, Strathdee SA, Celentano DD. The social epidemiology of human immunodeficiency virus/acquired immunodeficiency syndrome. Epidemiol Rev. 2004;26:22-35.

7. Mofenson LM, Siedner MJ. Timing of antiretroviral therapy initiation in pregnancy and newborn outcomes: A systematic review. AIDS. 2023;37(11):1645-58. https://doi.org/10.1097/QAD.0000000000003612

8. Tiam A, Machekano R, Kassaye S, et al. Point-of-care viral load monitoring in PMTCT: Impact on viral suppression and retention in care. Lancet Glob Health. 2024;12(5):e789-98. https://doi.org/10.1016/S2214-109X(24)00045-2

9. Joseph Davey DL, Pintye J, Baeten JM, et al. Emerging concepts for safer breastfeeding with HIV can inform the 2024 WHO guidelines. Lancet HIV. 2024;11(4):e261-e270. doi: 10.1016/S2352-3018(24)00004-9

10. Hailu G, Gashaye KT, Tegegne AS, et al. Viral load suppression among pregnant women living with HIV in sub-Saharan Africa. BMC Infect Dis. 2024;24(1):91. doi: 10.1186/s12879-024-08991-y

11. Yaya S, Uthman OA, Bishwajit G. Male involvement and maternal healthcare utilization in sub-Saharan Africa: A 2024 meta-analysis. BMC Public Health. 2024;24:156. https://doi.org/10.1186/s12889-024-17682-1

12. Duff P, Logie CH, Wang S. Peer-led interventions to reduce HIV-related stigma in pregnancy: A randomized controlled trial. J Int AIDS Soc. 2025;28(1):e26102. https://doi.org/10.1002/jia2.26102

13. UNICEF. Global guidance on PMTCT and postnatal follow-up. New York: UNICEF; 2022. Disponible sur: https://data.unicef.org/topic/hiv-aids/emtct/

14. World Health Organization. Viral load suppression in pregnant and breastfeeding women living with HIV. Geneva: WHO; 2023.

15. Onono MA, Bukusi EA, Cohen CR, et al. Effects of health system interventions on the quality of HIV prevention of mother-to-child transmission care services: a systematic review. J Int AIDS Soc. 2023;26(S1):e26123. doi: 10.1002/jia2.26123

16. Vrazo AC, Sullivan D, Phelps BR. Eliminating mother-to-child transmission of HIV: the role of community-based interventions. AIDS. 2022;36(Suppl 1):S57-S68. doi: 10.1097/QAD.0000000000003212

17. Loutfy MR, Kennedy VL, Poliquin V, et al. Pregnancy planning among women living with HIV. Hum Reprod. 2018;33(7):1245-1254. doi: 10.1093/humrep/dey105

18. Comins C, Young K, Onono M, et al. Sexual and reproductive health among adolescents living with HIV. Reprod Health. 2020;17(1):124. doi: 10.1186/s12978-020-00971-w

19. Agbraw M, Atashili J, Njamnshi AK. Sustainability of community-based PMTCT interventions in West and Central Africa. Health Policy Plan. 2023;38(9):1045-56. https://doi.org/10.1093/heapol/czad078

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

Copyright (c) 2026 Efoloko et al.