Abstract
Diabetes is frequently complicated by urinary tract infections (UTIs), and rising antimicrobial resistance increasingly undermines treatment effectiveness, especially in African settings. To estimate UTI frequency among diabetic patients in Kinshasa, identify causative pathogens, and describe their antibiotic resistance profiles. A descriptive cross-sectional study was conducted at AKRAM Hospital Center (Matete, Kinshasa) from January 15 to November 20, 2025, including 125 diabetic patients with urinary symptoms. Midstream urine samples were processed for culture/identification and disk-diffusion susceptibility testing on Mueller-Hinton agar, interpreted using CLSI/EUCAST criteria. Women accounted for 60.8% of participants; the 46-60-year age group was the most represented (32%). Cultures were sterile in 57.6% of cases. Among positive cultures, Escherichia coli was the most frequent pathogen (17.6%), followed by Klebsiella pneumoniae (7.2%) and Citrobacter diversus (6.4%). Overall, 60.4% of isolates were resistant to tested antibiotics. UTIs in diabetic patients in Kinshasa remain common and are associated with high antimicrobial resistance. Culture and susceptibility testing should guide therapy, alongside strengthened antibiotic stewardship.
References
1. Hossain MJ, Al‐Mamun M, Islam MR. Diabetes mellitus, the fastest growing global public health concern: Early detection should be focused. Health Science Reports. 2024;7(3):e2004.
2. Antar SA, Ashour NA, Sharaky M, Khattab M, Ashour NA, Zaid RT, et al. Diabetes mellitus: Classification, mediators, and complications; A gate to identify potential targets for the development of new effective treatments. Biomedicine & Pharmacotherapy. 2023;168:115734.
3. Paudel S, John PP, Poorbaghi SL, Randis TM, Kulkarni R. Systematic review of literature examining bacterial urinary tract infections in diabetes. Journal of Diabetes Research. 2022;2022(1):3588297.
4. Wahidin M, Achadi A, Besral B, Kosen S, Nadjib M, Nurwahyuni A, et al. Projection of diabetes morbidity and mortality till 2045 in Indonesia based on risk factors and NCD prevention and control programs. Scientific reports. 2024;14(1):5424.
5. Zhang Y-B, Pan X-F, Lu Q, Wang Y-X, Geng T-T, Zhou Y-F, et al. Associations of combined healthy lifestyles with cancer morbidity and mortality among individuals with diabetes: results from five cohort studies in the USA, the UK and China. Diabetologia. 2022;65(12):2044-55.
6. Herrera D, Sanz M, Shapira L, Brotons C, Chapple I, Frese T, et al. Association between periodontal diseases and cardiovascular diseases, diabetes and respiratory diseases: Consensus report of the Joint Workshop by the European Federation of Periodontology (EFP) and the European arm of the World Organization of Family Doctors (WONCA Europe). Journal of Clinical Periodontology. 2023;50(6):819-41.
7. Mwang'onde BJ, McHami JI. The aetiology and prevalence of urinary tract infections in Sub-Saharan Africa: a Systematic Review. Journal of Health & Biological Sciences. 2022;10(1):1-7.
8. Alemayehu E, Fiseha T, Bambo GM, Sahile Kebede S, Bisetegn H, Tilahun M, et al. Prevalence of hyperuricemia among type 2 diabetes mellitus patients in Africa: a systematic review and meta-analysis. BMC Endocrine Disorders. 2023;23(1):153.
9. Ching C, Schwartz L, Spencer JD, Becknell B. Innate immunity and urinary tract infection. Pediatric nephrology. 2020;35(7):1183-92.
10. Kuhn HW, Hreha TN, Hunstad DA. Immune defenses in the urinary tract. Trends in immunology. 2023;44(9):701-11.
11. Zhou Y, Zhou Z, Zheng L, Gong Z, Li Y, Jin Y, et al. Urinary tract infections caused by uropathogenic Escherichia coli: mechanisms of infection and treatment options. International journal of molecular sciences. 2023;24(13):10537.
12. Jalil MB, Al Atbee MYN. The prevalence of multiple drug resistance Escherichia coli and Klebsiella pneumoniae isolated from patients with urinary tract infections. Journal of clinical laboratory analysis. 2022;36(9):e24619.
13. Fendereski A, Ahani AA, Dadgar T. Phenotypic detection of Beta-lactamases among Proteus mirabilis, Enterobacter cloacae, and citrobacter freundii isolates from urinary samples in Gorgan, Northeast Iran. 2020.
14. Who CO. World health organization. Air Quality Guidelines for Europe. 2020(91).
15. Saeedi P, Salpea P, Karuranga S, Petersohn I, Malanda B, Gregg EW, et al. Mortality attributable to diabetes in 20–79 years old adults, 2019 estimates: Results from the International Diabetes Federation Diabetes Atlas. Diabetes research and clinical practice. 2020;162:108086.
16. Sinclair A, Saeedi P, Kaundal A, Karuranga S, Malanda B, Williams R. Diabetes and global ageing among 65–99-year-old adults: Findings from the International Diabetes Federation Diabetes Atlas. Diabetes research and clinical practice. 2020;162:108078.
17. Salari N, Karami MM, Bokaee S, Chaleshgar M, Shohaimi S, Akbari H, et al. The prevalence of urinary tract infections in type 2 diabetic patients: a systematic review and meta-analysis. European journal of medical research. 2022;27(1):20.
18. Ahmed AE, Abdelkarim S, Zenida M, Baiti MAH, Alhazmi AAY, Alfaifi BAH, et al. Prevalence and associated risk factors of urinary tract infection among diabetic patients: a cross-sectional study. In Healthcare 2023;11(6):861.
19. Kaur P, Kumar Sachan RS, Karnwal A, Devgon I. A Review on Clinical Manifestation and Treatment Regimens of UTI in Diabetic Patients. Iranian Journal of Medical Microbiology. 2022;16(2).
20. Akash MSH, Rehman K, Fiayyaz F, Sabir S, Khurshid M. Diabetes-associated infections: development of antimicrobial resistance and possible treatment strategies. Archives of microbiology. 2020;202(5):953-65.
21. Ka O. Profil des diabétiques hospitalisés au service de Médecine Interne de l’hôpital Ndamatou de Touba, Sénégal. Mali Santé Publique. 2021:19-25.
22. Bendale KA, Priya C, Jaiswal B. Urinary tract infection in diabetic patients: Etiology and antibiotic sensitivity conducted at selected hospitals. Journal of Contemporary Clinical Practice. 2025;11:509-14.
23. Kim B, Kim J-H, Lee Y. Virulence factors associated with Escherichia coli bacteremia and urinary tract infection. Annals of Laboratory Medicine. 2022;42(2):203-12.
24. Sonkoue Lambou JC, Noubom M, Djoumsie Gomseu BE, Takougoum Marbou WJ, Tamokou J-D-D, Gatsing D. Multidrug‐Resistant Escherichia coli causing urinary tract infections among controlled and uncontrolled type 2 diabetic patients at laquintinie hospital in Douala, Cameroon. Canadian Journal of Infectious Diseases and Medical Microbiology. 2022;2022(1):1250264.
25. Rus M, Licker M, Musuroi C, Muntean D, Vulpie S, Magiar O, et al. Association of Proteus mirabilis and Providencia stuartii infections with diabetes. Medicina. 2022;58(2):271.
26. Suwisi AS, Abdulkareem TA, Busnina RO, Alamami EM, Kalifa FA, Mohamed NA, et al. Postoperative Nosocomial Infections and Antimicrobial Resistance Pattern of Bacteria Isolates among Patients Admitted Al Jalla Hospital. Derna Academy Journal for Applied Sciences. 2023;1(2):90-9.
27. Hamdan A, AbuHaweeleh MN, Al-Qassem L, Kashkoul A, Alremawi I, Hussain U, et al. Prevalence of Antimicrobial Resistance Among the WHO’s AWaRe Classified Antibiotics Used to Treat Urinary Tract Infections in Diabetic Women. Antibiotics. 2024;13(12):1218.

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
Copyright (c) 2026 Mazingo et al.
